In This SectionTexas Health Research & Education Institute
Disease or Condition
Neuro Degenerative Disorders / Parkison´s Disease
CLINICAL AND LABORATORY PROFILE OF PARKINSON’S PATIENTS (Neuro Degenerative Disorders / Parkison's Disease)
DETERMINATION OF CLINICAL AND LABORATORY PROFILE OF PARKINSON’S PATIENTS WHO WILL OBTAIN OPTIMAL BENEFIT FROM NEUROSURGERY.
Subjects for this study will be all those subjects who are considering having DBS surgery for their Parkinson’s disease.
Patients will be recruited from the Movement Disorder Clinic at Presbyterian Hospital of Dallas or referrals from movement disorder specialist or neurologists with special interests in movement disorders.
Patients with atypical Parkinson’s disease such as Multiple Systems Atrophy, supranuclear palsy, normopressure hydrocephalus, gait disability from lacunar state, and corticobasogangionic degeneration.
The criteria for surgery are medication responsive typical Parkinson’s disease including the UK Brain Bank criteria for clinically definite Parkinson’s disease including the presence of bradykinesia and at least one other cardinal symptom of PD such as tremors and/or rigidity; responsiveness to levo-dopa medication, presence of motor fluctuations and/or dyskinesias and patient age generally younger than 90 years.
The presence of cognitive impairment (Folstein’s mini-mental examination status MMSE of = 28-30; and 8-10 on the clock drawing and clock copying tests (reference).
Presence of major psychiatric or behavioral illness; presence of uncontrolled diabetes and cardiovascular disease including the presence of a cardiac pacemaker.
In addition those who have a mini mental status examination consistent with cognitive impairment (MMSE less than 25) will usually be excluded because of the known effect of DBS in subjects with cognitive impairment as well as the difficulty in performance using the laboratory equipment.
In addition, subjects with uncontrolled diabetes, uncontrolled depression and suicidal ideation, uncontrolled seizures, subjects on childbearing potential, heart pacemakers, and those on coumadin will be excluded from evaluation since these are contraindication for DBS surgery.