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In This Section Texas Health Research & Education Institute

Clinical Trials

Disease or Condition   Heart / Myocardial Infarction
Title   Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients With Acute Coronary Syndrome (TRA‚ÄĘCER) (Heart / Myocardial Infarction)
Description   The study is designed to determine whether an investigational medicine, when added to the existing standard of care (eg, aspirin, clopidogrel) for preventing heart attack and stroke in patients with acute coronary syndrome, will yield additional benefit over the existing standard of care in preventing heart attack and stroke. The study is also designed to assess risk of bleeding with the investigational medicine added to the standard of care versus the standard of care alone.
IRB Number   Pro458
Inclusion/Notes   INCLUSION:
  • Men and women at least 18 years old with current clinical manifestation of non-ST-segment-elevation myocardial infarction (heart attack) according to the following three criteria:
  • Current symptoms of cardiac ischemia (chest pain leading to cardiac ischemia or heart attack).

  • AND
    either of the following:
  • Concurrent elevation of troponin I or T, or of creatine kinase - myocardial band (CK-MB) to a level above the upper limit of normal, OR.

  • Concurrent appropriate electrocardiographic evidence.
  • Documented history of peripheral arterial disease.

EXCLUSION:
  • Patients with a history of intracranial hemorrhage or of CNS surgery, tumor, or aneurysm.

  • Patients with any bleeding disorder or abnormality.

  • Patients with sustained severe hypertension or valvular heart disease.

  • Patients with a current or recent platelet count <100,000/cumm.

  • Patients with a planned or ongoing treatment with a blood thinning medication.

  • Patients who are pregnant.
Status   Completed
Location   Texas Health Harris Methodist Fort Worth
Principal Name    Vijay G Kalaria MD
Contact Name   Melissa South
Phone   (817) 820-4956

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