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In This Section Texas Health Research & Education Institute

Clinical Trials

Disease or Condition   Critical Care / Traumatic Brain Injury
Title   Hypertonic Resuscitation Following Traumatic Brain Injury (Critical Care / Traumatic Brain Injury)
Description   This research is being done because severe injury to the head can also decrease blood flow to the brain. In order to restore the blood pressure and blood flow, the paramedics give IV fluids as soon as possible. This is called “resuscitation”. The fluid most commonly used is “isotonic” (one that is the same concentration as the blood). We are trying to determine if IV “hypertonic” fluid (one more concentrated than the blood) can restore blood flow more efficiently.
IRB Number   Pro0077
Inclusion/Notes   INCLUSION:

Hypovolemic Shock Cohort
  • Blunt or Penetrating Trauma

  • Prehospital SBP =70 OR
    Prehospital SBP 71-90 AND HR=108

  • Age =15yrs or =50kg

TBI Cohort
  • Blunt trauma

  • Prehospital GCS = 8*

  • Age=15yrs or =50kg

*Patients with both a GCS = 8 & who meet the criteria for the hypovolemic shock cohort will be considered part of the hypovolemic shock cohort but will have assessment of neurologic outcome for subsequent subset analysis.

  • Known or suspected pregnancy

  • Age <15 or <50kg if age unknown

  • Ongoing prehospital Cardiopulmonary Resuscitation (CPR)

  • Administration of > 2000cc crystalloid or any colloid, blood products or Mannitol

  • Severe hypothermia (suspected T <28C)

  • Drowning or asphyxia due to hanging.

  • Burns TBSA > 20% in adults

  • Isolated penetrating injury to the head

  • Inability to obtain prehospital intravenous access

  • Time of call received at dispatch to study intervention > four hours

  • Known prisoners
Status   Completed
Location   Texas Health Fort Worth - Texas Health Southwest

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