In This SectionTexas Health Research & Education Institute
Disease or Condition
Critical Care / Traumatic Brain Injury
Hypertonic Resuscitation Following Traumatic Brain Injury (Critical Care / Traumatic Brain Injury)
This research is being done because severe injury to the head can also decrease blood flow to the brain. In order to restore the blood pressure and blood flow, the paramedics give IV fluids as soon as possible. This is called “resuscitation”. The fluid most commonly used is “isotonic” (one that is the same concentration as the blood). We are trying to determine if IV “hypertonic” fluid (one more concentrated than the blood) can restore blood flow more efficiently.
Hypovolemic Shock Cohort
Blunt or Penetrating Trauma
Prehospital SBP =70 OR
Prehospital SBP 71-90 AND HR=108
Age =15yrs or =50kg
Prehospital GCS = 8*
Age=15yrs or =50kg
*Patients with both a GCS = 8 & who meet the criteria for the hypovolemic shock cohort will be considered part of the hypovolemic shock cohort but will have assessment of neurologic outcome for subsequent subset analysis.