Benjamin D. Levine, M.D., FACC
Benjamin D. Levine, M.D., FACC

Professor of Internal Medicine,
UT Southwestern Medical Center

Dr. Levine is the founder and Director of the Institute for Exercise and Environmental Medicine (IEEM) at Texas Health Presbyterian Hospital Dallas where he also holds the S. Finley Ewing Chair for Wellness and the Harry S. Moss Heart Chair for Cardiovascular Research. He is Professor of Internal Medicine/Cardiology and Distinguished Professor of Exercise Sciences at the University of Texas Southwestern Medical Center. Dr. Levine earned his B.A. magna cum laude in human biology from Brown University and his M.D. from Harvard Medical School. He completed his internship and residency in internal medicine at Stanford University Medical Center followed by a cardiology fellowship at UT Southwestern where he trained under the renowned cardiovascular physiologists Gunnar Blomqivst, M.D. and Jere Mitchell, M.D. Dr. Levine founded the IEEM in 1992 which has become one of the premier laboratories in the world for the study of human clinical and integrative physiology. His global research interests center on the adaptive capacity of the circulation in response to exercise training, deconditioning, aging, and environmental stimuli such as spaceflight and high altitude. A Henry Luce Foundation and Fulbright Scholar, he received the Peter van Handel Award from the United States Olympic Committee (for outstanding research), the Research Award from the Wilderness Medical Society, the Honor Award from the Texas Chapter of American College of Sports Medicine (ACSM), and the Citation Award from the National ACSM for his body of work. A consummate clinician and teacher as well as a scholar, he was elected to the Association of University Cardiologists, the American Association of Physicians, received the Michael J. Joyner International Teaching Award from the Danish Cardiovascular Research Academy, and has been selected as one of the “Best Doctors” for cardiovascular medicine in Dallas and America multiple times by his peers.

Dr. Levine is a renowned sports cardiologist who sees athletes with cardiovascular medical problems from around the world and serves as a consultant to the NCAA, the NHL, the NFL, the USOC, USA Track and Field, and other athletic organizations. He has been a key contributor to the guidelines for the management of athletes with heart disease since 1994. Dr. Levine also has a unique background in space medicine, serving as a co-investigator on 4 Spacelab missions (SLS-1, SLS-2, D-2 and Neurolab), the MIR space station, and recently was the PI of a large cardiovascular experiment on the International Space Station (ISS), called the “ICV”. He was also awarded by NASA the “most Compelling Results from the ISS” in 2013. He has a long, sustained track record of funding by the NIH, NASA and the National Space Biomedical Research Institute (NSBRI), for which he was Team Leader of the Cardiovascular Section in 2007 to 2017 advising NASA’s flight surgeons on cardiovascular medical issues. His work with astronauts has translated into one of his other areas of clinical expertise, namely patients with syncope (fainting) and orthostatic intolerance (the inability to stand up and withstand the effects of gravity on Earth). Dr. Levine is currently the director of a Program Project grant that explores the “Mechanisms of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction: Precision Therapy Based on Patient Specific Pathophysiology”.

Dr. Levine has published 398 peer-reviewed journal articles, reviews, book chapters, and technical papers, and is currently serving on the editorial boards of numerous journals, Dr. Levine is a Fellow of the American College of Sports Medicine (ACSM), American Heart Association, the American College of Cardiology, and the Cardiovascular Section of the American Physiological Society; he served as VP and member of the Board of Trustees of ACSM, and as a member of the Board of Directors of the American Autonomic Society, elected member of the prestigious medical society the Association of American Physicians, and awarded the Distinguished Scientist Award (Translational Domain) by the American College of Cardiology in 2020.

Principal Investigator, Cardiovascular Physiology Autonomic Function Laboratory
Medical Director, Sports Cardiology Clinic
Medical Director, Syncope and Autonomic Dysfunction Clinic
Director, Institute for Exercise and Environmental Medicine
Texas Health Presbyterian Dallas

Education

  • Brown University, Providence, RI - B.A. Biology - 1978
  • Harvard Medical School, Boston, MA - M.D. Medicine - 1982
  • Stanford University Medical Center, Stanford, CA - Internal Medicine Residency - 1985
  • Shinshu University, Matsumoto, Japan - Environmental Physiology Fellowship - 1986
  • UT Southwestern Medical Center, Dallas, TX - Cardiology Fellowship - 1989

Contact Information

Phone: 214-345-6459
Email: BenjaminLevine@TexasHealth.org

Highlighted Publications
  • Daily Generation of a Footward Fluid Shift Attenuates Ocular Changes Associated with Head-Down Tilt Bedrest
    Lawley JS, Babu G, Janssen SLJE, Petersen LG, Hearon CM, Dias KA, Sarma S, Williams MA, Whitworth LA, Levine BD. Daily Generation of a Footward Fluid Shift Attenuates Ocular Changes Associated with Head-Down Tilt Bedrest.  J Appl Physiol (1985). 2020 Sep 17. doi: 10.1152/japplphysiol.00250.2020. Online ahead of print. PMID: 32940563.
    https://pubmed.ncbi.nlm.nih.gov/32940563/
  • Non-invasive Assessment of Cardiac Output: Accuracy and Precision of the Closed-Circuit Acetylene Rebreathing Technique for Cardiac Output Measurement
    Hardin EA, Stoller D, Lawley JS, Howden EJ, Hieda M, Jarvis S, Sarma S, et al, Levine BD. Non-invasive Assessment of Cardiac Output: Accuracy and Precision of the Closed-Circuit Acetylene Rebreathing Technique for Cardiac Output Measurement. J Am Heart Assoc. 2020 Sep;9(17):e015794. doi: 10.1161/JAHA.120.015794. Epub 2020 Aug 27.J Am Heart Assoc. 2020. PMID: 32851906.
    https://pubmed.ncbi.nlm.nih.gov/32851906/
  • Training-Associated Changes in Ventricular Volumes and Function in Elite Female Runners
    Churchill TW, Groezinger E, Loomer G, Guseh JS, Weiner RB, Wasfy MM, Levine BD, Baggish AL.  Training-Associated Changes in Ventricular Volumes and Function in Elite Female Runners. Circ Cardiovasc Imaging. 2020;13:e010567. PMID: 32482135.
    DOI: 10.1161/CIRCIMAGING.120.010567. https://pubmed.ncbi.nlm.nih.gov/32482135/
  • The Effect of Lifelong Endurance Exercise on Cardiovascular Structure and Exercise Function in Women
    Carrick-Ranson GC, Sloane NM, Howden EJ, Bhella PS, Sarma S, Shibata S, Fujimoto N, Hastings J, and Levine BD. The Effect of Lifelong Endurance Exercise on Cardiovascular Structure and Exercise Function in Women. J Physiol. 2020 Jul;598(13):2589-2605. doi: 10.1113/JP278503. Epub 2020 May 21. PMID: 32347540; PMCID: PMC7347229.
    https://pubmed.ncbi.nlm.nih.gov/32347540/
  • Increased Myocardial Stiffness in Patients with High Risk Left Ventricular Hypertrophy
    Hieda M, Sarma S, Levine BD, et al. Increased Myocardial Stiffness in Patients with High Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B HFpEF.  Circ. 141(2), 115-123, 2020, PMID: 31865771; PMCID: PMC7194118.
    https://pubmed.ncbi.nlm.nih.gov/31865771/
  • Web-based Multimedia Athlete Preparticipation Questionnaire: Introducing the video-PPE
    Parizher G, Putzke, Lampert R, Emery MS, Baggish A, Martinez M, Levine A, Levine BD. Web-based Multimedia Athlete Preparticipation Questionnaire: Introducing the video-PPE (v-PPE). BR J Sports Med, 54(1), 67-68, 2020. PMID: 31076397.
    https://pubmed.ncbi.nlm.nih.gov/31076397/
  • Iron Insufficiency Diminishes the Erythropoietic Response to Moderate Altitude Exposure
    Okazaki K, Stray-Gundersen J, Chapman RF, Levine BD. Iron Insufficiency Diminishes the Erythropoietic Response to Moderate Altitude Exposure.  J Appl Physiol, 127(6) 1569-1578, 2019. PMID: 31670602.
    https://pubmed.ncbi.nlm.nih.gov/31670602/
  • Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction
    Hearon CM, Levine BD, et al. Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction. Heart, 105 (20), 1552-1558, 2019. PMID: 31208971.
    https://pubmed.ncbi.nlm.nih.gov/31208971/
  • Mechanisms of Left Atrial Enlargement in Obesity
    Aiad NN, Hearon C Jr., Hieda M, Dias K, Levine BD, Sarma S. Mechanisms of Left Atrial Enlargement in Obesity.  Am J Cardiol.  124(3):442-447, 2019, PMID:  31133275.
    https://pubmed.ncbi.nlm.nih.gov/31133275/
  • The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives
    Stembridge M, Williams AM, Gasho C, Dawkins TG, Drane A, Villafuerte FC, Levine BD, Shave R, ip N Ainslie PN.   The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives. Proc Natl Acad Sci U S A. 2019;116(33):16177-16179. PMID: 31358634; PMCID: PMC6697886. doi: 10.1073/pnas.1909002116.
    https://pubmed.ncbi.nlm.nih.gov/31358634/
  • Association of All-Cause and Cardiovascular Mortality with High Levels of Physical Activity and Concurrent Coronary Artery Calcification
    DeFina LF, Radford NB, Barlow CE, Willis BL, Leonard D, Haskell WL, Farrell SW, Pavlovic A, Abek K. Berry JD, Khera A, Levine BD. Association of All-Cause and Cardiovascular Mortality with High Levels of Physical Activity and Concurrent Coronary Artery Calcification.  JAMA Cardiol 4(2):174-181, 2019. PMID: 30698608; PMCID: PMC6439619.
    https://pubmed.ncbi.nlm.nih.gov/30698608/
  • Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity Exercise Training in Sedentary Middle-Aged Adults
    McNamara DA, Aiad N, Howden EJ, Hieda M, Link MS, Palmer MD, Samels MS, Everding B, Ng J, Adams-Huet B, Opondo M, Sarma S, Levine BD. Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity Exercise Training in Sedentary Middle-Aged Adults.  Circ, 139(12):1507-1516, 2019. PMID: 30586729, PMCID: PMC6422706.
    https://pubmed.ncbi.nlm.nih.gov/30586729/
  • No heartbreak at high altitude; preserved cardiac function in chronic hypoxia
    Stembridge M, Levine BD.  No heartbreak at high altitude; preserved cardiac function in chronic hypoxia. Exp Physiol. 104(5):619-620, 2019.  PMID:  30905067.
    https://pubmed.ncbi.nlm.nih.gov/30905067/
  • The Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium Atherosclerotic Cardiovascular Disease Risk Calculator
    Khera Amit, Budoff MJ, O’Donnell CJ, Ayers CA, Locke J, de Lemos JA, Massaro JM, McClelland RL, Taylor A, Levine BD. The Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium Atherosclerotic Cardiovascular Disease Risk Calculator. Circulation. 138(17):1819-1827, 2018. PMID: 30354651.
    https://pubmed.ncbi.nlm.nih.gov/30354651/
  • The effect of lifelong exercise frequency on arterial stiffness
    Shibata S, Fujimoto N, Hastings JL, Carrick-Ranson G, Bhella PS, Hearon C, Levine BD.  The effect of lifelong exercise frequency on arterial stiffness.  J Physiol, 596 (14):2783-95, 2018. PMID: 29781119; PMCID: PMC6046080.
    https://pubmed.ncbi.nlm.nih.gov/29781119/
  • Cardiorespiratory Fitness, Coronary Artery Calcium and Cardiovascular Disease Events in a cohort of generally healthy, middle aged men: Results from the Cooper Center Longitudinal Study
    Radford NB, DeFina LF, Leonard D, Barlow CE, Willis BL, Gibbons LW, Gilchrist SC, Khera A, Levine BD.  Cardiorespiratory Fitness, Coronary Artery Calcium and Cardiovascular Disease Events in a cohort of generally healthy, middle aged men: Results from the Cooper Center Longitudinal Study. Circulation, 137(18):1888-1895, 2018.  PMID:  29343464.
    https://pubmed.ncbi.nlm.nih.gov/29343464/
  • Effects of Prolonged Space Flight on Atrial Size, Atrial Electrophysiology, and Risk of Atrial Fibrillation
    Khine HW, Steding-Ehrenborg K, Hastings JL, Kowal J, Daniels J, Page RL, Goldberger JJ, Ng J, Bungo MW, Adams-Huet B, Levine BD.  Effects of Prolonged Space Flight on Atrial Size, Atrial Electrophysiology, and Risk of Atrial Fibrillation.  Circ: Arrhythmia Electrophysiol, 11(5):e005959, 2018. PMID: 29752376.
    https://pubmed.ncbi.nlm.nih.gov/29752376/
  • Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention
    Howden E, Sarma S, Lawley J, Opondo M, Cornwell W, Stoller D, Urey M, Adams-Huet B, Levine BD. Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention. Circulation, 137(15):1549-1560, 2018. PMID:  29311053, PMCID: PMC5893372.
    https://pubmed.ncbi.nlm.nih.gov/29311053/
  • Effect of gravity and microgravity on intracranial pressure
    Lawley JS, Petersen LG, Howden EJ, Sarma S, Cornwell WK, Zhang R, Whitworth LA, Williams MA, Levine BD.  Effect of gravity and microgravity on intracranial pressure.  J Physiol. 2017 Mar 15; 595(6):2115-2127. PMID:  28092926; PMCID: PMC5350445.
    https://pubmed.ncbi.nlm.nih.gov/28092926/
  • Lifelong Physical Activity Regardless of Dose Is Not Associated with Myocardial Fibrosis
    Abdullah SM, Barkley KW, Bhella PS, Hastings JL, Matulevicius S, Fujimoto N, Shibata S, Carrick-Ranson G, Palmer MD, Gandhi N, DeFina LF, Levine BD.  Lifelong Physical Activity Regardless of Dose Is Not Associated with Myocardial Fibrosis.  Circ Cardiovasc Imaging, 9(11):e005511, 2016.  PMID: 27903541, PMCID: PMC5137797.
    https://pubmed.ncbi.nlm.nih.gov/27903541/
  • Effect of pulsatile and nonpulsatile flow on cerebral perfusion in patients with left ventricular assist devices.

    Cornwell WK, Tarumi T, Aengevaeren VL, Ayers C, Divanji P, Fu Q, Palmer MD, Drazner MH, Meyer DM, Bethea BT, Hastings JL, Fujimoto N, Shibata S, Zhang, R, Markham DW, Levine BD. Effect of pulsatile and nonpulsatile flow on cerebral perfusion in patients with left ventricular assist devices.   J Heart and Lung Transplantation, 33(12):1295-303, 2014. PMID:  25307621. https://pubmed.ncbi.nlm.nih.gov/25307621/

  • Restoration of pulsatile flow reduces sympathetic nerve activity among individuals with continuous-flow left ventricular assist devices

    Cornwell WK 3rd, Tarumi T, Palmer D, Drazner MH, Meyer DM, Bethea BT, Hastings JL, Fujimoto N Shibata S, Zhang R, Markham DW, Fu Q, and Levine BD. Restoration of pulsatile flow reduces sympathetic nerve activity among individuals with continuous-flow left ventricular assist devices. Circulation, 132(24):2316-22, 2015. PMID: 26510698. https://pubmed.ncbi.nlm.nih.gov/26510698/

  • Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial

    Howden E, Sarma S, Lawley J, Opondo M, Cornwell W, Stoller D, Urey M, Adams-Huet B, Levine BD. Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention. Circulation, 137(15):1549-1560, 2018. PMID:  29311053, PMCID: PMC5893372. https://pubmed.ncbi.nlm.nih.gov/29311053/

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